Antilymphoid antibody preconditioning and tacrolimus monotherapy for pediatric kidney transplantation
نویسندگان
چکیده
منابع مشابه
Antilymphoid antibody preconditioning and tacrolimus monotherapy for pediatric kidney transplantation.
OBJECTIVE Heavy post-transplant immunosuppression may contribute to long-term immunosuppression dependence by subverting tolerogenic mechanisms; thus, we sought to determine if this undesirable consequence could be mitigated by pretransplant lymphoid depletion and minimalistic post-transplant monotherapy. STUDY DESIGN Lymphoid depletion in 17 unselected pediatric recipients of live (n = 14) o...
متن کاملAlemtuzumab pre-conditioning with tacrolimus monotherapy in pediatric renal transplantation.
We employed antibody pre-conditioning with alemtuzumab and posttransplant immunosuppression with low-dose tacrolimus monotherapy in 26 consecutive pediatric kidney transplant recipients between January 2004 and December 2005. Mean recipient age was 10.7 +/- 5.8 years, 7.7% were undergoing retransplantation, and 3.8% were sensitized, with a PRA >20%. Mean donor age was 32.8 +/- 9.2 years. Living...
متن کاملPediatric kidney transplantation: An overview
Kidney Transplantation in children is the treatment of choice to treat end stage renal disease. Improvements in immunosuppressive management have dramatically reduced the risk of early acute rejection and graft loss, however the long term results in terms of graft survival and morbidity still require search for new immunosuppressive regimens. Reducing of side effects are the challenges for impr...
متن کاملTacrolimus related neurologic complication after pediatric kidney transplantation
Recently significant neurotoxicity has been reported with the use of carcineurin inhibitors. An 11-year-old-girl had undergone a transplantation of kidney from her mother. On post-operative day 12, hypertension, headache, and left motor weakness (grade I) suddenly occurred. The brain-magnetic resonance imaging and magnetic resonance angiography showed acute cerebral infarction at subcortical wh...
متن کاملLiving donor renal transplantation using alemtuzumab induction and tacrolimus monotherapy.
Alemtuzumab was used as an induction agent in 205 renal transplant recipients undergoing 207 living donor renal transplants. All donor kidneys were recovered laparoscopically. Postoperatively, patients were treated with tacrolimus monotherapy, and immunosuppression was weaned when possible. Forty-seven recipients of living donor renal transplants prior to the induction era who received conventi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Pediatrics
سال: 2006
ISSN: 0022-3476
DOI: 10.1016/j.jpeds.2006.01.008